The ketogenic diet improves cognition and has biochemical effects in the prefrontal cortex that are dissociable from hippocampus

This paper describes a study that used a ketogenic diet (KD) as a global metabolic strategy for improving brain function in young and aged rats. After 12 weeks, rats were trained to perform a spatial alternation task through an asymmetrical maze, in which one arm was closed and the other was open. The data from this animal study suggests that KDs could be optimal for enhancing large-scale network function that is critical for higher cognition.